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Investigation was in fact analyzed from the about three-way ANOVA with pairwise testing with Tukey’s post hoc attempt

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Investigation was in fact analyzed from the about three-way ANOVA with pairwise testing with Tukey’s post hoc attempt

Associations

The primary goal of this study was to analyze urinary Na + , K + and the Na + :K + excretion ratio, for associations with changes in systolic blood pressure (SBP) in participants from the DASH–Sodium trial during the initial screening period in which participants were consuming their regular diet without dietary intervention. The secondary goals of quizy hookup this study were to investigate: (a) the impact of the salt sensitivity of blood pressure on these responses and (b) the impact of the DASH–Sodium dietary intervention, which lowers SBP and increases dietary K + intake, on these potential associations. Our analysis reports that in the DASH–Sodium study cohort: (1) a daily excretion of <1 g K + /day is associated with elevated SBP, (2) urinary K + excretion of >1 g/day does not correlate with a reduction in SBP and, (3) a reduction in the urinary Na + :K + excretion ratio is not associated with lower SBP irrespective of the salt sensitivity of blood pressure. Collectively our data support the recent DRI recommendation not to propose a DRI for K + and suggest that further evidence is required to support the establishment of a Na + /K + excretion ratio that would reduce SBP in the general population.

Logical variables

Indicate SBP in line with urinary salt to help you potassium (Na + /K + ) removal ratio in the course of screening along with dieting input out of Slimming down Remedies for Avoid Blood pressure level (DASH) high sodium (HS) and you may lower sodium (LS) eating plan in (a) sodium sensitive and painful (letter = 71), (b) sodium resistant (n = 119) anybody, philosophy revealed as imply ± SD.

Significantly, we observed no association between the urinary Na + :K + ratio and SBP on the DASH HS or DASH LS dietary intervention in either SS (DASH HS R 2 = 0.04, DASH LS R 2 = 0.02) or SR (DASH HS R 2 = 0.04, DASH LS R 2 = 0.00002) participants (Fig. 5a, b). The DASH dietary intervention significantly increased the number of participants in both SS and SR groups with a urinary Na + :K + ratio of <1 on both the HS and LS diet. However, the urinary Na + :K + had no impact on SBP within dietary intake groups (Fig. 6a, b). Further, when expressed as a frequency distribution histogram the change in SBP from the DASH HS to LS dietary intervention exhibits a profound leftward shift in the SS group compared to SR group (Fig. 7a). In contrast, the frequency distribution histogram for change in the urinary Na + :K + ratio from the DASH HS to LS dietary intervention shows no difference in the Gaussian curve and distribution between SS and SR participants (Fig. 7b).

Then, numerous research has suggested your blood pressure level cures evoked of the K + intake are influenced by weight loss Na + intake [twenty-eight, 29]. Inside our studies of your Dashboard-Salt dataset i observed no organization which have urinary K + removal and you can SBP, for the patient testing see otherwise during the Dashboard weight reduction intervention whenever Na + intake are modified, indicating an independence of ramifications of Na + and K + towards the SBP inside investigation. New 2019 DRI Report figured you will find insufficient facts into the the effects away from K + with the blood pressure and you will don’t introduce a beneficial DRI out-of K + . All of our research secure the 2019 DRI Declaration and you can means that fat loss K + supplementation may not rather eliminate blood circulation pressure on standard populace.

Summary

Stamler J, Flower Grams, Stamler Roentgen, Elliott P, Dyer A great, Marmot M. INTERSALT data results. Public health and health care effects. Blood pressure. 1989;–7.

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